Recycling Mitsunobu coupling: a shortcut for troublesome esterifications
نویسندگان
چکیده
منابع مشابه
Use of sonication for the coupling of sterically hindered substrates in the phenolic Mitsunobu reaction.
A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high concentration combined with sonication.
متن کاملDiversity-oriented synthesis of dihydrobenzoxazepinones by coupling the Ugi multicomponent reaction with a Mitsunobu cyclization
An operationally simple protocol for the synthesis of 2,3-dihydrobenzo[f][1,4]oxazepin-3-ones, based on an Ugi reaction of an ortho-(benzyloxy)benzylamine, glycolic acid, an isocyanide and an aldehyde, followed by an intramolecular Mitsunobu substitution was developed. The required ortho-(benzyloxy)benzylamines have been in situ generated from the corresponding azides, in turn prepared in high ...
متن کاملOrganocatalytic Mitsunobu reactions.
A catalytic Mitsunobu reaction system is described in which the azo reagent is used as an organocatalyst and iodosobenzene diacetate is used as the stoichiometric oxidant. In this system, iodosobenzene diacetate oxidizes the formed hydrazine byproduct to regenerate the azo reagent. Yields obtained in the catalytic reactions using a variety of carboxylic acids and alcohols were slightly lower th...
متن کاملThe troublesome probabilistic powerdomain
In [12] it is shown that the probabilistic powerdomain of a continuous domain is again continuous. The category of continuous domains, however, is not cartesian closed, and one has to look at subcategories such as RB, the retracts of bifinite domains. [8] offers a proof that the probabilistic powerdomain construction can be restricted to RB. In this paper, we give a counterexample to Graham’s p...
متن کاملAlternative Schools for Troublesome Secondary Students
Results of a field experiment indicate that a certain kind of secondary school program reduced the disruptive behavior and improved the scholastic performance of students who were about to be suspended or expelled from their conventional schools. The research indicates that the program was demonstrably effective only with those students who were not at the outset extremely depressed and anxious...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tetrahedron
سال: 2016
ISSN: 0040-4020
DOI: 10.1016/j.tet.2016.09.065